Derivation of pluripotent epiblast stem cells from mammalian embryos

I. Gabrielle M. Brons, Lucy E. Smithers, Matthew W. B. Trotter, Peter Rugg-Gunn, Bowen Sun, Susana M. Chuva de Sousa Lopes, Sarah K. Howlett, Amanda Clarkson, Lars Ahrlund-Richter, Roger A. Pedersen and Ludovic Vallier ()
Additional contact information
I. Gabrielle M. Brons: Addenbrooke’s Hospital, University of Cambridge, Cambridge CB2 0XY, UK
Lucy E. Smithers: CR-UK Viral Oncology Group, Wolfson Institute for Biomedical Research, UCL, Cruciform Building Gower Street, London WC1E 6BT, UK
Matthew W. B. Trotter: CR-UK Viral Oncology Group, Wolfson Institute for Biomedical Research, UCL, Cruciform Building Gower Street, London WC1E 6BT, UK
Peter Rugg-Gunn: Addenbrooke’s Hospital, University of Cambridge, Cambridge CB2 0XY, UK
Bowen Sun: Addenbrooke’s Hospital, University of Cambridge, Cambridge CB2 0XY, UK
Susana M. Chuva de Sousa Lopes: University of Cambridge, Tennis Court Road, Cambridge CB2, 1QR, UK
Sarah K. Howlett: Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, University of Cambridge, Cambridge CB2 0XY, UK
Amanda Clarkson: Kefford House Maris Lane Cambridge CB2 2FF, UK
Lars Ahrlund-Richter: Dept of Laboratory Medicine Clinical Research Centre, Karolinska University Hospital Karolinska Institutet 141 57 Stockholm, Sweden
Roger A. Pedersen: Addenbrooke’s Hospital, University of Cambridge, Cambridge CB2 0XY, UK
Ludovic Vallier: Addenbrooke’s Hospital, University of Cambridge, Cambridge CB2 0XY, UK

Nature, 2007, vol. 448, issue 7150, 191-195

Abstract: A new type of stem cell Human embryonic stem (ES) cells are potentially important in therapy because they are pluripotent, capable of differentiating into virtually any cell type given appropriate encouragement. One obstacle to progress in research on them has been the baffling differences between human and mouse ES cells. Now two groups working independently have created a new kind of pluripotent ES cell. Derived from mouse embryos after they implant in the wall of the uterus, these EpiSCs (epiblast stem cells) are distinct from 'classic' mouse ES cells and mirror key features of human ES cells. The discovery of EpiSCs should provide an important experimental model to accelerate the use of human ES cells in research and eventually perhaps, in therapy.

Date: 2007
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DOI: 10.1038/nature05950

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