New cell lines from mouse epiblast share defining features with human embryonic stem cells

Paul J. Tesar (), Josh G. Chenoweth, Frances A. Brook, Timothy J. Davies, Edward P. Evans, David L. Mack, Richard L. Gardner and Ronald D. G. McKay ()
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Paul J. Tesar: Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
Josh G. Chenoweth: Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
Frances A. Brook: Mammalian Development Laboratory, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Timothy J. Davies: Mammalian Development Laboratory, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Edward P. Evans: Mammalian Development Laboratory, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
David L. Mack: Stem Cell Biology Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Richard L. Gardner: Mammalian Development Laboratory, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Ronald D. G. McKay: Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA

Nature, 2007, vol. 448, issue 7150, 196-199

Abstract: A new type of stem cell Human embryonic stem (ES) cells are potentially important in therapy because they are pluripotent, capable of differentiating into virtually any cell type given appropriate encouragement. One obstacle to progress in research on them has been the baffling differences between human and mouse ES cells. Now two groups working independently have created a new kind of pluripotent ES cell. Derived from mouse embryos after they implant in the wall of the uterus, these EpiSCs (epiblast stem cells) are distinct from 'classic' mouse ES cells and mirror key features of human ES cells. The discovery of EpiSCs should provide an important experimental model to accelerate the use of human ES cells in research and eventually perhaps, in therapy.

Date: 2007
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DOI: 10.1038/nature05972

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