The Rab8 GTPase regulates apical protein localization in intestinal cells

Takashi Sato, Sotaro Mushiake, Yukio Kato, Ken Sato, Miyuki Sato, Naoki Takeda, Keiichi Ozono, Kazunori Miki, Yoshiyuki Kubo, Akira Tsuji, Reiko Harada and Akihiro Harada ()
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Takashi Sato: Laboratory of Molecular Traffic, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371-8512, Japan
Sotaro Mushiake: Osaka University Graduate School of Medicine, Osaka 565-0871, Japan
Yukio Kato: Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920-1192, Japan
Ken Sato: Laboratory of Molecular Traffic, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371-8512, Japan
Miyuki Sato: Laboratory of Molecular Traffic, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371-8512, Japan
Naoki Takeda: Center for Animal Resources and Development (CARD), IRDA, Kumamoto University, Kumamoto 860-0811, Japan
Keiichi Ozono: Osaka University Graduate School of Medicine, Osaka 565-0871, Japan
Kazunori Miki: Itami Municipal Hospital, Hyogo 664-8540, Japan
Yoshiyuki Kubo: Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920-1192, Japan
Akira Tsuji: Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920-1192, Japan
Reiko Harada: Laboratory of Molecular Traffic, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371-8512, Japan
Akihiro Harada: Laboratory of Molecular Traffic, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371-8512, Japan

Nature, 2007, vol. 448, issue 7151, 366-369

Abstract: Rab8 is a small GTP-binding protein thought to regulate basolateral transport in vitro. In this paper, Rab8 conditional knockout mice are used to show that Rab8 plays an important part in vivo in the maintenance of the apical surface of intestinal cells; the mice eventually starve owing to poor absorption of food.

Date: 2007
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DOI: 10.1038/nature05929

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