Delayed ageing through damage protection by the Arf/p53 pathway

Ander Matheu, Antonio Maraver, Peter Klatt, Ignacio Flores, Isabel Garcia-Cao, Consuelo Borras, Juana M. Flores, Jose Viña, Maria A. Blasco and Manuel Serrano ()
Additional contact information
Ander Matheu: Tumor Suppression Group,
Antonio Maraver: Tumor Suppression Group,
Peter Klatt: Tumor Suppression Group,
Ignacio Flores: Telomeres and Telomerase Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain
Isabel Garcia-Cao: Tumor Suppression Group,
Consuelo Borras: University of Valencia, Valencia 46010, Spain
Juana M. Flores: Complutense University of Madrid, Madrid 28040, Spain
Jose Viña: University of Valencia, Valencia 46010, Spain
Maria A. Blasco: Telomeres and Telomerase Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain
Manuel Serrano: Tumor Suppression Group,

Nature, 2007, vol. 448, issue 7151, 375-379

Abstract: Ageing and cancer linked The tumour suppressor activities of p53 protein and its regulator, Arf, are based on their involvement in detecting and eliminating damaged cells. Like cancer, ageing is associated with the accumulation of cellular damage and starting from that premise, Matheu et al. show that mice with increased, but otherwise normally regulated, levels of p53 and Arf are not only resistant to cancers, but also have a longer lifespan than normal mice regardless of the effects of the cancer. Remarkably, biological and molecular markers of ageing indicate that these mice stay 'younger' longer. Boosting endogenous Arf/p53 activity appears to provide an anti-oxidant effect that both suppresses cancers and delays ageing.

Date: 2007
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DOI: 10.1038/nature05949

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