Two distinct modes of guidance signalling during collective migration of border cells

Ambra Bianco, Minna Poukkula, Adam Cliffe, Juliette Mathieu, Carlos M. Luque, Tudor A. Fulga and Pernille Rørth ()
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Ambra Bianco: European Molecular Biology Laboratory, Heidelberg, 69117, Germany
Minna Poukkula: European Molecular Biology Laboratory, Heidelberg, 69117, Germany
Adam Cliffe: European Molecular Biology Laboratory, Heidelberg, 69117, Germany
Juliette Mathieu: European Molecular Biology Laboratory, Heidelberg, 69117, Germany
Carlos M. Luque: European Molecular Biology Laboratory, Heidelberg, 69117, Germany
Tudor A. Fulga: European Molecular Biology Laboratory, Heidelberg, 69117, Germany
Pernille Rørth: European Molecular Biology Laboratory, Heidelberg, 69117, Germany

Nature, 2007, vol. 448, issue 7151, 362-365

Abstract: Cell migration The movement of groups of cells during development and tumour metastasis is poorly understood. A handle on the process is provided by border cell migration in the Drosophila ovary, a powerful model for the regulation of cell migration and guidance in vivo. Using Drosophila's sophisticated genetics, and innovative live imaging, Bianco et al. show that border cells migrate in two phases. First, cells migrate posteriorly in a fast mode. For the second half of posterior migration, and for dorsal migration, border cells move slowly as a compact cluster and cells begin to shuffle within clusters. The two migration modes have quite distinct sensitivities to receptor tyrosine kinase signalling pathways and the cell cluster processes information as a group, making use of the difference in signalling levels between individual cells.

Date: 2007
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DOI: 10.1038/nature05965

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