Variants conferring risk of atrial fibrillation on chromosome 4q25

Daniel F. Gudbjartsson (), David O. Arnar, Anna Helgadottir, Solveig Gretarsdottir, Hilma Holm, Asgeir Sigurdsson, Adalbjorg Jonasdottir, Adam Baker, Gudmar Thorleifsson, Kristleifur Kristjansson, Arnar Palsson, Thorarinn Blondal, Patrick Sulem, Valgerdur M. Backman, Gudmundur A. Hardarson, Ebba Palsdottir, Agnar Helgason, Runa Sigurjonsdottir, Jon T. Sverrisson, Konstantinos Kostulas, Maggie C. Y. Ng, Larry Baum, Wing Yee So, Ka Sing Wong, Juliana C. N. Chan, Karen L. Furie, Steven M. Greenberg, Michelle Sale, Peter Kelly, Calum A. MacRae, Eric E. Smith, Jonathan Rosand, Jan Hillert, Ronald C. W. Ma, Patrick T. Ellinor, Gudmundur Thorgeirsson, Jeffrey R. Gulcher, Augustine Kong, Unnur Thorsteinsdottir and Kari Stefansson ()
Additional contact information
Daniel F. Gudbjartsson: deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland
David O. Arnar: Landspitali University Hospital, 101 Reykjavik, Iceland
Anna Helgadottir: deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland
Solveig Gretarsdottir: deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland
Hilma Holm: Landspitali University Hospital, 101 Reykjavik, Iceland
Asgeir Sigurdsson: deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland
Adalbjorg Jonasdottir: deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland
Adam Baker: deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland
Gudmar Thorleifsson: deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland
Kristleifur Kristjansson: deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland
Arnar Palsson: deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland
Thorarinn Blondal: deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland
Patrick Sulem: deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland
Valgerdur M. Backman: deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland
Gudmundur A. Hardarson: deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland
Ebba Palsdottir: deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland
Agnar Helgason: deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland
Runa Sigurjonsdottir: Landspitali University Hospital, 101 Reykjavik, Iceland
Jon T. Sverrisson: Akureyri Regional Hospital, 600 Akureyri, Iceland
Konstantinos Kostulas: Karolinska Institutet at Karolinska University Hospital, Huddinge S-141 86, Sweden
Maggie C. Y. Ng: Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong
Larry Baum: Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong
Wing Yee So: Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong
Ka Sing Wong: Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong
Juliana C. N. Chan: Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong
Karen L. Furie: Department of Neurology,
Steven M. Greenberg: Department of Neurology,
Michelle Sale: Department of Neurology,
Peter Kelly: Department of Neurology,
Calum A. MacRae: Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Eric E. Smith: Department of Neurology,
Jonathan Rosand: Department of Neurology,
Jan Hillert: Karolinska Institutet at Karolinska University Hospital, Huddinge S-141 86, Sweden
Ronald C. W. Ma: Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong
Patrick T. Ellinor: Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Gudmundur Thorgeirsson: Landspitali University Hospital, 101 Reykjavik, Iceland
Jeffrey R. Gulcher: deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland
Augustine Kong: deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland
Unnur Thorsteinsdottir: deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland
Kari Stefansson: deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland

Nature, 2007, vol. 448, issue 7151, 353-357

Abstract: Take heart A genome-wide association scan in populations from Sweden, North America and China has identified two single-letter sequence variants on chromosome 4q25 as risk factors for atrial fibrillation, the most common form of cardiac arrhythmia. Both are adjacent to the PITX2 gene, known to be involved in early heart development. This work identifies PITX2 as a target for diagnostic tests and possibly for therapeutic intervention.

Date: 2007
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DOI: 10.1038/nature06007

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