Protective and therapeutic role for αB-crystallin in autoimmune demyelination

Shalina S. Ousman, Beren H. Tomooka, Johannes M. van Noort, Eric F. Wawrousek, Kevin O’Conner, David A. Hafler, Raymond A. Sobel, William H. Robinson and Lawrence Steinman ()
Additional contact information
Shalina S. Ousman: Stanford University
Beren H. Tomooka: Stanford University School of Medicine, Stanford, California 94305, USA
Johannes M. van Noort: TNO Quality of Life, 2301 CE Leiden, The Netherlands
Eric F. Wawrousek: National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Kevin O’Conner: Center for Neurologic Disease, Harvard Medical School, Brigham and Women's Hospital, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
David A. Hafler: Center for Neurologic Disease, Harvard Medical School, Brigham and Women's Hospital, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Raymond A. Sobel: Laboratory Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
William H. Robinson: Stanford University School of Medicine, Stanford, California 94305, USA
Lawrence Steinman: Stanford University

Nature, 2007, vol. 448, issue 7152, 474-479

Abstract: Pivotal to multiple sclerosis? The protein αB-crystallin, found primarily in the lens of the eye, could be the critical 'tipping point' in the spiral of inflammation and damage that occurs in multiple sclerosis. It was known to be a major immune target in multiple sclerosis patients. Now work in mice shows that the protein plays a protective role in a model of multiple sclerosis. When injected in mice it acts as an anti-inflammatory and neuroprotective factor and can also reverse paralysis.

Date: 2007
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DOI: 10.1038/nature05935

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