IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells

Thomas Korn, Estelle Bettelli, Wenda Gao, Amit Awasthi, Anneli Jäger, Terry B. Strom, Mohamed Oukka () and Vijay K. Kuchroo ()
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Thomas Korn: Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Estelle Bettelli: Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Wenda Gao: Transplant Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
Amit Awasthi: Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, Massachusetts 02139, USA
Anneli Jäger: Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Terry B. Strom: Transplant Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
Mohamed Oukka: Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, Massachusetts 02139, USA
Vijay K. Kuchroo: Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA

Nature, 2007, vol. 448, issue 7152, 484-487

Abstract: TH17 cells are a recently defined subset of pro-inflammatory helper T cells that are induced by the cytokines IL-6 and transforming growth factor (TGF)-β. TH17 can also be induced by an alternative pathway in which TGF-β cooperates with IL-21.

Date: 2007
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DOI: 10.1038/nature05970

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