A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum

Hidde L. Ploegh ()
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Hidde L. Ploegh: Whitehead Institute, Cambridge, Massachusetts 02142, USA

Nature, 2007, vol. 448, issue 7152, 435-438

Abstract: Ditch the 'dislocon'? A protein channel has been hypothesized as a component of the endoplasmic reticulum (ER) to account for the fact that misfolded proteins and non-enveloped viruses can pass through the ER into the cytoplasm. Der1 protein in yeast and the Derlins in other eukaryotes are examples of protein types that might function in such a dislocation channel or 'dislocon'. But Hidde Ploegh, writing in our occasional Hypothesis series, suggests an alternative mechanism that might do the job without the need for a protein-based channel. Instead, an escape hatch triggered by lipid rearrangement would allow both proteins and viruses to traverse the ER.

Date: 2007
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DOI: 10.1038/nature06004

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