DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

Akinori Takaoka, ZhiChao Wang, Myoung Kwon Choi, Hideyuki Yanai, Hideo Negishi, Tatsuma Ban, Yan Lu, Makoto Miyagishi, Tatsuhiko Kodama, Kenya Honda, Yusuke Ohba and Tadatsugu Taniguchi ()
Additional contact information
Akinori Takaoka: and
ZhiChao Wang: and
Myoung Kwon Choi: and
Hideyuki Yanai: and
Hideo Negishi: and
Tatsuma Ban: and
Yan Lu: and
Makoto Miyagishi: Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan
Tatsuhiko Kodama: Research Center for Advanced Science and Technology, University of Tokyo, Komaba 4-6-1, Meguro-ku, Tokyo 153-8904, Japan
Kenya Honda: and
Yusuke Ohba: Hokkaido University Graduate School of Medicine, N15, W7, Kita-ku, Sapporo 060-0815, Japan
Tadatsugu Taniguchi: and

Nature, 2007, vol. 448, issue 7152, 501-505

Abstract: DNA and immunity DNA is a potent activator of immune responses. This has been known for more than 40 years, but the mechanism involved is still unclear. Now Takaoka et al. have identified a cytosolic DNA sensor that's involved in the innate immune response. The molecule is interferon-inducible protein DLM-1/ZBP1. No biological function had been found for this before, hence a renaming as DAI, (for DNA-dependent activator of IFN-regulatory factors). The identification of DAI as a key DNA sensor may offer new insight into the signalling mechanisms underlying DNA associated antimicrobial immunity and autoimmune disorders.

Date: 2007
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DOI: 10.1038/nature06013

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