Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma

Miriam F. Moffatt, Michael Kabesch, Liming Liang, Anna L. Dixon, David Strachan, Simon Heath, Martin Depner, Andrea von Berg, Albrecht Bufe, Ernst Rietschel, Andrea Heinzmann, Burkard Simma, Thomas Frischer, Saffron A. G. Willis-Owen, Kenny C. C. Wong, Thomas Illig, Christian Vogelberg, Stephan K. Weiland, Erika von Mutius, Gonçalo R. Abecasis, Martin Farrall, Ivo G. Gut, G. Mark Lathrop and William O. C. Cookson ()
Additional contact information
Miriam F. Moffatt: National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
Michael Kabesch: University Children's Hospital, Ludwig Maximilians University, D80337 Munich, Germany
Liming Liang: Center for Statistical Genetics, SPH II, Ann Arbor, Michigan 48109-2029, USA
Anna L. Dixon: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
David Strachan: St George's, University of London, London SW17 0RE, UK
Simon Heath: Centre National de Génotypage, Institut Génomique, Commissariat à l'Énergie Atomique, 91057 Evry, France
Martin Depner: University Children's Hospital, Ludwig Maximilians University, D80337 Munich, Germany
Andrea von Berg: Research Institute for the Prevention of Allergic Diseases, Marien-Hospital, D46483 Wesel, Germany
Albrecht Bufe: Ruhr-University, D44789 Bochum, Germany
Ernst Rietschel: University Children's Hospital, University of Cologne, D50924 Cologne, Germany
Andrea Heinzmann: University Children's Hospital, Albert Ludwigs University, D79106 Freiburg, Germany
Burkard Simma: Feldkirch Hospital, A6800 Feldkirch, Austria
Thomas Frischer: University Children's Hospital Vienna, A1090 Vienna, Austria
Saffron A. G. Willis-Owen: National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
Kenny C. C. Wong: National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
Thomas Illig: Institute of Epidemiology, GSF-Research Centre for Environment and Health, D85764 Neuherberg, Germany
Christian Vogelberg: University Children's Hospital, Technical University Dresden, D01307 Dresden, Germany
Stephan K. Weiland: Institute of Epidemiology, Ulm University, D89081 Germany
Erika von Mutius: University Children's Hospital, Ludwig Maximilians University, D80337 Munich, Germany
Gonçalo R. Abecasis: Center for Statistical Genetics, SPH II, Ann Arbor, Michigan 48109-2029, USA
Martin Farrall: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
Ivo G. Gut: Centre National de Génotypage, Institut Génomique, Commissariat à l'Énergie Atomique, 91057 Evry, France
G. Mark Lathrop: Centre National de Génotypage, Institut Génomique, Commissariat à l'Énergie Atomique, 91057 Evry, France
William O. C. Cookson: National Heart and Lung Institute, Imperial College, London SW3 6LY, UK

Nature, 2007, vol. 448, issue 7152, 470-473

Abstract: Childhood asthma genes Rates of childhood asthma diagnosis are rising: 6% of children in the United States are sufferers. Both genetic and environmental factors are clearly important. To discover more about the genetic element, Moffatt et al. looked for genes linked to asthma in a genome-wide association scan. More than a third of children with asthma of onset below the age of seven showed variations in expression of the ORMDL3 gene on chromosome 17. Similar genes are found in yeast and other primitive organisms, suggesting that they may be components of an ancient and conserved immune mechanism.

Date: 2007
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DOI: 10.1038/nature06014

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