Common effector processing mediates cell-specific responses to stimuli

Kathryn Miller-Jensen, Kevin A. Janes, Joan S. Brugge and Douglas A. Lauffenburger ()
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Kathryn Miller-Jensen: Center for Cell Decision Processes, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Kevin A. Janes: Center for Cell Decision Processes, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Joan S. Brugge: Harvard Medical School, Boston, Massachusetts 02115, USA
Douglas A. Lauffenburger: Center for Cell Decision Processes, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA

Nature, 2007, vol. 448, issue 7153, 604-608

Abstract: Mixed signals The fundamental components of many signalling pathways are common to most cells in an organism. So why do different cell types respond differently to the same stimulus? A novel systems-modelling approach to this question, focusing on two distinct epithelial cell lines, reveals that cell specificity is mainly determined by the type, strength and combination of upstream signalling events. These cell-type specific signals are integrated by common effectors to create cell-type specific outcomes. Resolving the enigma of cell specificity is important to understanding embryonic development, organismal homeostasis and the side effects of targeted therapeutics.

Date: 2007
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DOI: 10.1038/nature06001

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