A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene

Hakon Hakonarson (), Struan F. A. Grant, Jonathan P. Bradfield, Luc Marchand, Cecilia E. Kim, Joseph T. Glessner, Rosemarie Grabs, Tracy Casalunovo, Shayne P. Taback, Edward C. Frackelton, Margaret L. Lawson, Luke J. Robinson, Robert Skraban, Yang Lu, Rosetta M. Chiavacci, Charles A. Stanley, Susan E. Kirsch, Eric F. Rappaport, Jordan S. Orange, Dimitri S. Monos, Marcella Devoto, Hui-Qi Qu and Constantin Polychronakos ()
Additional contact information
Hakon Hakonarson: Center for Applied Genomics, and,
Struan F. A. Grant: Center for Applied Genomics, and,
Jonathan P. Bradfield: Center for Applied Genomics, and,
Luc Marchand: McGill University, Montreal H3H 1P3, Québec, Canada
Cecilia E. Kim: Center for Applied Genomics, and,
Joseph T. Glessner: Center for Applied Genomics, and,
Rosemarie Grabs: McGill University, Montreal H3H 1P3, Québec, Canada
Tracy Casalunovo: Center for Applied Genomics, and,
Shayne P. Taback: University of Manitoba, Winnipeg R3E 0Z2, Manitoba, Canada
Edward C. Frackelton: Center for Applied Genomics, and,
Margaret L. Lawson: Children’s Hospital of Eastern Ontario, University of Ottawa, Ottawa K1H 8L1, Ontario, Canada
Luke J. Robinson: Center for Applied Genomics, and,
Robert Skraban: Center for Applied Genomics, and,
Yang Lu: McGill University, Montreal H3H 1P3, Québec, Canada
Rosetta M. Chiavacci: Center for Applied Genomics, and,
Charles A. Stanley: The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Susan E. Kirsch: Markham-Stouffville Hospital, Markham L3P 7P3, Ontario, Canada
Eric F. Rappaport: The Children’s Hospital of Philadelphia Nucleic Acid and Protein Core, Philadelphia, Pennsylvania 19104, USA
Jordan S. Orange: University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104, USA
Dimitri S. Monos: Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Marcella Devoto: and
Hui-Qi Qu: McGill University, Montreal H3H 1P3, Québec, Canada
Constantin Polychronakos: McGill University, Montreal H3H 1P3, Québec, Canada

Nature, 2007, vol. 448, issue 7153, 591-594

Abstract: Novel diabetes gene The discovery of a gene newly implicated in the pathogenesis of type 1 diabetes may boost the development of predictive tests. A genome-wide association study on DNA from more than 500 patients with type 1 diabetes confirms associations with known type-1-diabetes-related genes and a new link to the KIAA0350 gene. This encodes a sugar-binding C-type lectin, one of a group of proteins whose functions include carbohydrate recognition and cell adhesion.

Date: 2007
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DOI: 10.1038/nature06010

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