Behavioural improvements with thalamic stimulation after severe traumatic brain injury

N. D. Schiff, J. T. Giacino, K. Kalmar, J. D. Victor, K. Baker, M. Gerber, B. Fritz, B. Eisenberg, J. O’Connor, E. J. Kobylarz, S. Farris, A. Machado, C. McCagg, F. Plum, J. J. Fins and A. R. Rezai
Additional contact information
N. D. Schiff: Weill Cornell Medical College, New York, New York 10021, USA
J. T. Giacino: JFK Johnson Rehabilitation Institute, Edison, New Jersey 08818, USA
K. Kalmar: JFK Johnson Rehabilitation Institute, Edison, New Jersey 08818, USA
J. D. Victor: Weill Cornell Medical College, New York, New York 10021, USA
K. Baker: Center for Neurologic Restoration, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
M. Gerber: JFK Johnson Rehabilitation Institute, Edison, New Jersey 08818, USA
B. Fritz: JFK Johnson Rehabilitation Institute, Edison, New Jersey 08818, USA
B. Eisenberg: JFK Johnson Rehabilitation Institute, Edison, New Jersey 08818, USA
J. O’Connor: JFK Johnson Rehabilitation Institute, Edison, New Jersey 08818, USA
E. J. Kobylarz: Weill Cornell Medical College, New York, New York 10021, USA
S. Farris: Center for Neurologic Restoration, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
A. Machado: Center for Neurologic Restoration, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
C. McCagg: JFK Johnson Rehabilitation Institute, Edison, New Jersey 08818, USA
F. Plum: Weill Cornell Medical College, New York, New York 10021, USA
J. J. Fins: Weill Cornell Medical College, New York, New York 10021, USA
A. R. Rezai: Center for Neurologic Restoration, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA

Nature, 2007, vol. 448, issue 7153, 600-603

Abstract: Brain activity revived At present there is no reliable way of enhancing recovery from extended loss of consciousness in patients with traumatic brain injury. But recent evidence suggesting that a level of cerebral activity is preserved in some minimally conscious patients has raised interest in the topic. In a single subject study, Schiff et al. show that bilateral deep brain stimulation in the thalamus in a minimally conscious state following brain injury can increase behavioural responsiveness and function. The observations, made six years after the injury, challenge current thinking on the management of patients with severe brain injury.

Date: 2007
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DOI: 10.1038/nature06041

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