Crystallographic evidence for deviating C3b structure (Reply)

A. Abdul Ajees, Krishnasamy Gunasekaran (), Sthanam V. L. Narayana and H. M. Krishna Murthy
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A. Abdul Ajees: Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham
Krishnasamy Gunasekaran: Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham
Sthanam V. L. Narayana: Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham
H. M. Krishna Murthy: Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham

Nature, 2007, vol. 448, issue 7154, E2-E3

Abstract: Abstract We concur with Janssen et al. 1 that the structure of C3b that we reported (Protein Data Bank entry 2HR0)2 differs from the other two (2ICF (ref. 3) and 2I07 (ref. 4) in the conformation of the CUB and TED domains. The deviation of 2HR0 from 2I07 is probably relevant physiologically, considering that CUB eventually unfolds.

Date: 2007
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DOI: 10.1038/nature06103

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