The common biology of cancer and ageing

Toren Finkel (), Manuel Serrano and Maria A. Blasco
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Toren Finkel: Cardiology Branch, NIH, NHLBI, Building 10/CRC 5-3330, 10 Center Drive, Bethesda, Maryland 20892, USA
Manuel Serrano: Spanish National Cancer Research Center (CNIO) 3 Melchor Fernandez Almagro Street, Madrid 28029, Spain
Maria A. Blasco: Spanish National Cancer Research Center (CNIO) 3 Melchor Fernandez Almagro Street, Madrid 28029, Spain

Nature, 2007, vol. 448, issue 7155, 767-774

Abstract: Cancer and ageing The peculiar form of immortality displayed by cancer cells and the ageing process that contributes to our mortality would seem to be opposites. But remarkably, the underlying biology of cancerous cells and ageing have converged. Genomic instability, telomere function and autophagy feature in papers on both cancer and ageing. Connections have emerged between tumorigenesis and cell senescence. And mitochondrial metabolism is key to both phenomena. Finkel et al. present a historical perspective of the common biology of cancer and ageing, from the first realization that human cancer cells — HeLa cells — could divide continuously in culture to the dawn of the systems biology approach.

Date: 2007
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DOI: 10.1038/nature05985

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