LKB1 modulates lung cancer differentiation and metastasis

Hongbin Ji, Matthew R. Ramsey, D. Neil Hayes, Cheng Fan, Kate McNamara, Piotr Kozlowski, Chad Torrice, Michael C. Wu, Takeshi Shimamura, Samanthi A. Perera, Mei-Chih Liang, Dongpo Cai, George N. Naumov, Lei Bao, Cristina M. Contreras, Danan Li, Liang Chen, Janakiraman Krishnamurthy, Jussi Koivunen, Lucian R. Chirieac, Robert F. Padera, Roderick T. Bronson, Neal I. Lindeman, David C. Christiani, Xihong Lin, Geoffrey I. Shapiro, Pasi A. Jänne, Bruce E. Johnson, Matthew Meyerson, David J. Kwiatkowski, Diego H. Castrillon, Nabeel Bardeesy (), Norman E. Sharpless () and Kwok-Kin Wong ()
Additional contact information
Hongbin Ji: Dana-Farber Cancer Institute
Matthew R. Ramsey: Department of Genetics,
D. Neil Hayes: Department of Medicine,
Cheng Fan: Department of Genetics,
Kate McNamara: Dana-Farber Cancer Institute
Piotr Kozlowski: Division of Translational Medicine,
Chad Torrice: Department of Medicine,
Michael C. Wu: Harvard School of Public Health
Takeshi Shimamura: Dana-Farber Cancer Institute
Samanthi A. Perera: Dana-Farber Cancer Institute
Mei-Chih Liang: Dana-Farber Cancer Institute
Dongpo Cai: Dana-Farber Cancer Institute
George N. Naumov: Children’s Hospital
Lei Bao: University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
Cristina M. Contreras: University of Texas Southwestern Medical Center, Dallas, Texas 75390-9072, USA
Danan Li: Dana-Farber Cancer Institute
Liang Chen: Dana-Farber Cancer Institute
Janakiraman Krishnamurthy: Department of Genetics,
Jussi Koivunen: Dana-Farber Cancer Institute
Lucian R. Chirieac: Department of Pathology,
Robert F. Padera: Department of Pathology,
Roderick T. Bronson: Harvard Medical School, Boston, Massachusetts 02115, USA
Neal I. Lindeman: Department of Pathology,
David C. Christiani: Department of Environmental Health,
Xihong Lin: Harvard School of Public Health
Geoffrey I. Shapiro: Dana-Farber Cancer Institute
Pasi A. Jänne: Dana-Farber Cancer Institute
Bruce E. Johnson: Dana-Farber Cancer Institute
Matthew Meyerson: Dana-Farber Cancer Institute
David J. Kwiatkowski: Division of Translational Medicine,
Diego H. Castrillon: University of Texas Southwestern Medical Center, Dallas, Texas 75390-9072, USA
Nabeel Bardeesy: Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Norman E. Sharpless: Department of Genetics,
Kwok-Kin Wong: Dana-Farber Cancer Institute

Nature, 2007, vol. 448, issue 7155, 807-810

Abstract: Lkb1 and cancer causation Mutations in the Lkb1 tumour suppressor gene are found in Peutz–Jeghers syndrome patients who have an increased incidence of cancers. Now Lkb1 mutations have been found in the squamous carcinoma subtype of non-small-cell lung cancers. In a mouse model for lung cancer in which Lkb1 loss is combined with K-Ras mutations, more aggressive tumours arise than with K-Ras mutations alone and often these are classified as squamous and large-cell carcinomas. Thus loss of Lkb1 modulates lung cancer differentiation, and Lkb1 loss may be a useful marker for predicting disease development and spread. The pathways regulated by LKB1 represent possible therapeutic targets.

Date: 2007
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DOI: 10.1038/nature06030

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