Small self-RNA generated by RNase L amplifies antiviral innate immunity

Krishnamurthy Malathi, Beihua Dong, Michael Gale and Robert H. Silverman ()
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Krishnamurthy Malathi: Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
Beihua Dong: Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
Michael Gale: School of Medicine University of Washington, 1959 NE Pacific Street, H-578 Health Sciences, Box 357650 Seattle, Washington 98195-7650, USA
Robert H. Silverman: Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA

Nature, 2007, vol. 448, issue 7155, 816-819

Abstract: Self confidence RNA molecules in virus-infected cells trigger interferon production and initiate antiviral innate immunity. Small RNA cleavage products from 'self' RNA generated by the antiviral endoribonuclease RNase L have now been found to initiate and amplify antiviral responses. This points to RNase L activation as a possible strategy for antiviral therapy.

Date: 2007
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DOI: 10.1038/nature06042

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