Cdk1 is sufficient to drive the mammalian cell cycle

David Santamaría, Cédric Barrière, Antonio Cerqueira, Sarah Hunt, Claudine Tardy, Kathryn Newton, Javier F. Cáceres, Pierre Dubus, Marcos Malumbres and Mariano Barbacid ()
Additional contact information
David Santamaría: Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO)
Cédric Barrière: Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO)
Antonio Cerqueira: Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO)
Sarah Hunt: Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO)
Claudine Tardy: Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO)
Kathryn Newton: MRC Human Genetics Unit, Western General Hospital
Javier F. Cáceres: MRC Human Genetics Unit, Western General Hospital
Pierre Dubus: EA2406 University of Bordeaux 2
Marcos Malumbres: Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO)
Mariano Barbacid: Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO)

Nature, 2007, vol. 448, issue 7155, 811-815

Abstract: Mouse lacking all interphase Cdks (Cdk2, Cdk3, Cdk4 and Cdk6) undergo organogenesis and develop to midgestation, and individual cells lacking all 3 kinases are able to proliferate. However, Cdk1 is shown to be absolutely essential for cell division during the first stages of embryonic development.

Date: 2007
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DOI: 10.1038/nature06046

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