Break-induced replication and telomerase-independent telomere maintenance require Pol32

John R. Lydeard, Suvi Jain, Miyuki Yamaguchi and James E. Haber ()
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John R. Lydeard: MS029 Rosenstiel Centre, Brandeis University, Waltham, Massachusetts 02454-9110, USA
Suvi Jain: MS029 Rosenstiel Centre, Brandeis University, Waltham, Massachusetts 02454-9110, USA
Miyuki Yamaguchi: MS029 Rosenstiel Centre, Brandeis University, Waltham, Massachusetts 02454-9110, USA
James E. Haber: MS029 Rosenstiel Centre, Brandeis University, Waltham, Massachusetts 02454-9110, USA

Nature, 2007, vol. 448, issue 7155, 820-823

Abstract: Break-induced replication repair (BIR) of a DNA double-strand break requires Polα and Polδ to initiate replication, while Polɛ is needed to extend the replication patch. This BIR also uniquely requires Pol32, a Polδ subunit that is not necessary for normal replication.

Date: 2007
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DOI: 10.1038/nature06047

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