Integrating molecular and network biology to decode endocytosis

Eva M. Schmid and Harvey T. McMahon ()
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Eva M. Schmid: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Harvey T. McMahon: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK

Nature, 2007, vol. 448, issue 7156, 883-888

Abstract: Inside story The strength of network biology lies in its ability to derive cell biological information without a priori mechanistic or molecular knowledge. Eva Schmid and Harvey McMahon show that a molecular understanding of clathrin-mediated endocytosis, a process used by eukaryotic cells to pack nutrients and other molecules into vesicles for internalization, can refine the network approach and allow the derivation of general biological principles.

Date: 2007
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DOI: 10.1038/nature06031

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