Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells

Hiroyuki Tezuka, Yukiko Abe, Makoto Iwata, Hajime Takeuchi, Hiromichi Ishikawa, Masayuki Matsushita, Tetsuo Shiohara, Shizuo Akira and Toshiaki Ohteki ()
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Hiroyuki Tezuka: Akita University Graduate School of Medicine
Yukiko Abe: Akita University Graduate School of Medicine
Makoto Iwata: Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University
Hajime Takeuchi: Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University
Hiromichi Ishikawa: Keio University School of Medicine
Masayuki Matsushita: Mitsubishi Kagaku Institute of Life Sciences
Tetsuo Shiohara: Kyorin University School of Medicine
Shizuo Akira: Research Institute for Microbial Diseases, Osaka University
Toshiaki Ohteki: Akita University Graduate School of Medicine

Nature, 2007, vol. 448, issue 7156, 929-933

Abstract: Immunoglobulin-A (IgA) is the main immunoglobulin found in mucous sectretions. B cell class-switch recombination to IgA in mucosa-associated tissues is regulated by a subset of dendritic cells which produce TNF-α and inducible nitric oxide in response to the recognition of commensal bacteria by toll-like receptors

Date: 2007
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DOI: 10.1038/nature06033

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