The effects of molecular noise and size control on variability in the budding yeast cell cycle

Stefano Di Talia, Jan M. Skotheim, James M. Bean, Eric D. Siggia and Frederick R. Cross ()
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Stefano Di Talia: The Rockefeller University
Jan M. Skotheim: Center for Studies in Physics and Biology, The Rockefeller University, New York, New York 10021, USA
James M. Bean: The Rockefeller University
Eric D. Siggia: Center for Studies in Physics and Biology, The Rockefeller University, New York, New York 10021, USA
Frederick R. Cross: The Rockefeller University

Nature, 2007, vol. 448, issue 7156, 947-951

Abstract: Reports on single cell experiments in budding yeast that analyse the role of molecular noise during the G1 phase of the cell cycle. Variability in the timing of G1 can be attributed to variations in cell size at cell birth, as well as variations of a size-independent 'timer' step. These two steps are modular and together control the timing of the critical Start transition of the G1 phase.

Date: 2007
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DOI: 10.1038/nature06072

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