p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a

Paul Krimpenfort, Annemieke IJpenberg, Ji-Ying Song, Martin van der Valk, Martijn Nawijn, John Zevenhoven and Anton Berns ()
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Paul Krimpenfort: Division of Molecular Genetics and Centre for Biomedical Genetics,
Annemieke IJpenberg: Division of Molecular Genetics and Centre for Biomedical Genetics,
Ji-Ying Song: The Netherlands Cancer Institute
Martin van der Valk: The Netherlands Cancer Institute
Martijn Nawijn: Division of Molecular Genetics and Centre for Biomedical Genetics,
John Zevenhoven: Division of Molecular Genetics and Centre for Biomedical Genetics,
Anton Berns: Division of Molecular Genetics and Centre for Biomedical Genetics,

Nature, 2007, vol. 448, issue 7156, 943-946

Abstract: A locus on chromosome 9p21 which encodes three cell cycle inhibitors is frequently deleted in human cancer. Two of these, p16INKa and p14ARF, function as tumour suppressors. A new mouse model now shows that a third, p15INK4b, also contributes to the tumour suppressor function of this locus. Mice lacking all three show enhanced tumourigenesis and a broader tumour spectrum.

Date: 2007
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DOI: 10.1038/nature06084

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