Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1

Eros Lazzerini Denchi and Titia de Lange ()
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Eros Lazzerini Denchi: Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
Titia de Lange: Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA

Nature, 2007, vol. 448, issue 7157, 1068-1071

Abstract: Double bluff The telomeres that cap normal chromosomes share virtually the same structure as damaged DNA sequences within chromosomes. So how do telomeres evade recognition by the DNA-repair machinery? Simple: two telomere binding proteins, TRF2 and POT1, block the activation of two key DNA damage response pathways. With TRF2 and POT1 inactivated, telomeres can be 'repaired' into the chromosomes where they don't belong.

Date: 2007
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DOI: 10.1038/nature06065

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