A sequence-based variation map of 8.27 million SNPs in inbred mouse strains

Kelly A. Frazer (), Eleazar Eskin, Hyun Min Kang, Molly A. Bogue, David A. Hinds, Erica J. Beilharz, Robert V. Gupta, Julie Montgomery, Matt M. Morenzoni, Geoffrey B. Nilsen, Charit L. Pethiyagoda, Laura L. Stuve, Frank M. Johnson, Mark J. Daly, Claire M. Wade and David R. Cox
Additional contact information
Kelly A. Frazer: Perlegen Sciences, 2021 Stierlin Court, Mountain View, California 94043, USA
Eleazar Eskin: University of California, Los Angeles, Los Angeles, California 90095, USA
Hyun Min Kang: University of California, San Diego, La Jolla, California 92093, USA
Molly A. Bogue: The Jackson Laboratory, Bar Harbor, Maine 04609, USA
David A. Hinds: Perlegen Sciences, 2021 Stierlin Court, Mountain View, California 94043, USA
Erica J. Beilharz: Perlegen Sciences, 2021 Stierlin Court, Mountain View, California 94043, USA
Robert V. Gupta: Perlegen Sciences, 2021 Stierlin Court, Mountain View, California 94043, USA
Julie Montgomery: Perlegen Sciences, 2021 Stierlin Court, Mountain View, California 94043, USA
Matt M. Morenzoni: Perlegen Sciences, 2021 Stierlin Court, Mountain View, California 94043, USA
Geoffrey B. Nilsen: Perlegen Sciences, 2021 Stierlin Court, Mountain View, California 94043, USA
Charit L. Pethiyagoda: Perlegen Sciences, 2021 Stierlin Court, Mountain View, California 94043, USA
Laura L. Stuve: Perlegen Sciences, 2021 Stierlin Court, Mountain View, California 94043, USA
Frank M. Johnson: Toxicology Operations Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Mark J. Daly: Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
Claire M. Wade: Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
David R. Cox: Perlegen Sciences, 2021 Stierlin Court, Mountain View, California 94043, USA

Nature, 2007, vol. 448, issue 7157, 1050-1053

Abstract: Putting mice on the HapMap A major new resource is now available to geneticists working on the many mouse models that are used to study toxicity and human disease. The genomes of four wild-derived and eleven inbred laboratory mouse strains have been resequenced to create a comprehensive resource of DNA variation. About 8.3 million single base-pair differences known as single nucleotide polymorphisms (SNPs) were identified. The data are publicly available as a mouse 'HapMap' at http://mouse.perlegen.com/ . The density and quality of this set of SNP markers is unprecedented for a mammalian genome, and it will provide a powerful tool for identifying the genetic determinants of phenotypic variation in the mouse.

Date: 2007
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature06067 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:448:y:2007:i:7157:d:10.1038_nature06067

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature06067

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().