Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon

Hongyan Wang, Yingshi Ouyang, W. Gregory Somers, William Chia () and Bingwei Lu ()
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Hongyan Wang: National University of Singapore
Yingshi Ouyang: Stanford University School of Medicine, Geriatric Research, Education and Clinical Center (GRECC)/VA Palo Alto Health Care System (VAPAHCS), Palo Alto, California 94304, USA
W. Gregory Somers: National University of Singapore
William Chia: National University of Singapore
Bingwei Lu: Stanford University School of Medicine, Geriatric Research, Education and Clinical Center (GRECC)/VA Palo Alto Health Care System (VAPAHCS), Palo Alto, California 94304, USA

Nature, 2007, vol. 449, issue 7158, 96-100

Abstract: A delicate balance A balance between self-renewal and differentiation is fundamental to stem cell and cancer biology. Drosophila neural stem cells achieve this through asymmetric cell division, during which factors influencing self-renewal and differentiation are unequally segregated. Wang et al. now show that the mitotic kinase Polo regulates the asymmetric localization of the tumour-suppressor protein Numb by phosphorylating Pon, the adaptor protein for Numb. Polo acts as a tumour suppressor by regulating Pon/Numb. These findings demonstrate a direct biochemical link between the cell cycle and asymmetric protein localization, and reveal a novel tumour suppressor mechanism.

Date: 2007
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DOI: 10.1038/nature06056

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