Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells

Piotr Kazmierczak, Hirofumi Sakaguchi, Joshua Tokita, Elizabeth M. Wilson-Kubalek, Ronald A. Milligan, Ulrich Müller () and Bechara Kachar ()
Additional contact information
Piotr Kazmierczak: The Scripps Research
Hirofumi Sakaguchi: Laboratory of Cellular Biology, National Institute on Deafness and other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
Joshua Tokita: Laboratory of Cellular Biology, National Institute on Deafness and other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
Elizabeth M. Wilson-Kubalek: The Scripps Research
Ronald A. Milligan: The Scripps Research
Ulrich Müller: The Scripps Research
Bechara Kachar: Laboratory of Cellular Biology, National Institute on Deafness and other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA

Nature, 2007, vol. 449, issue 7158, 87-91

Abstract: Tip-link structure revealed Hair cells of the inner ear are so-called because of the hair-like projections, or stereocilia, that protrude from their apical surface. Sound-induced stereocilial motion is thought to be coupled to mechanoelectrical transduction channels via the 'tip links' that connect stereocilia to one another. Kazmierczak et al. now report the composition of mammalian tip links. They are formed by the interaction of two members of the family of calcium-dependent cell adhesion proteins, cadherin and protocadherin 15. Interestingly, mutation of these cadherins causes deafness in humans and one such mutation disrupts the interaction between the two molecules.

Date: 2007
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DOI: 10.1038/nature06091

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