p53 is regulated by the lysine demethylase LSD1

Jing Huang, Roopsha Sengupta, Alexsandra B. Espejo, Min Gyu Lee, Jean A. Dorsey, Mario Richter, Susanne Opravil, Ramin Shiekhattar, Mark T. Bedford, Thomas Jenuwein and Shelley L. Berger ()
Additional contact information
Jing Huang: The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
Roopsha Sengupta: Research Institute of Molecular Pathology (IMP), The Vienna Biocenter, 1030 Vienna, Austria
Alexsandra B. Espejo: M. D. Anderson Cancer Center, University of Texas, Smithville, Texas 78957, USA
Min Gyu Lee: The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
Jean A. Dorsey: The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
Mario Richter: Research Institute of Molecular Pathology (IMP), The Vienna Biocenter, 1030 Vienna, Austria
Susanne Opravil: Research Institute of Molecular Pathology (IMP), The Vienna Biocenter, 1030 Vienna, Austria
Ramin Shiekhattar: The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
Mark T. Bedford: M. D. Anderson Cancer Center, University of Texas, Smithville, Texas 78957, USA
Thomas Jenuwein: Research Institute of Molecular Pathology (IMP), The Vienna Biocenter, 1030 Vienna, Austria
Shelley L. Berger: The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA

Nature, 2007, vol. 449, issue 7158, 105-108

Abstract: LSD1 reverses methylation of p53 at lysine 370 to repress p53-mediated transcriptional activation and apoptosis, and to prevent the interaction of p53 with 53BP1.

Date: 2007
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DOI: 10.1038/nature06092

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