Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity

Laura E. Parton, Chian Ping Ye, Roberto Coppari, Pablo J. Enriori, Brian Choi, Chen-Yu Zhang, Chun Xu, Claudia R. Vianna, Nina Balthasar, Charlotte E. Lee, Joel K. Elmquist, Michael A. Cowley () and Bradford B. Lowell ()
Additional contact information
Laura E. Parton: Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
Chian Ping Ye: Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
Roberto Coppari: Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
Pablo J. Enriori: Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, Oregon 97006, USA
Brian Choi: Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
Chen-Yu Zhang: Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
Chun Xu: Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, Oregon 97006, USA
Claudia R. Vianna: Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
Nina Balthasar: Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
Charlotte E. Lee: Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
Joel K. Elmquist: Center for Hypothalamic Research, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9077, USA
Michael A. Cowley: Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, Oregon 97006, USA
Bradford B. Lowell: Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA

Nature, 2007, vol. 449, issue 7159, 228-232

Abstract: Mice that cannot sense glucose with their pro-opiomelanocortin (POMC neurons) develop glucose intolerance, demonstrating that glucose sensing in neurons plays an important role in responding to a systemic glucose load. It is also shown that in mice with obesity-induced type 2 diabetes, glucose-sensing by POMC neurons is defective.

Date: 2007
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DOI: 10.1038/nature06098

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