Dscam diversity is essential for neuronal wiring and self-recognition

Daisuke Hattori, Ebru Demir, Ho Won Kim, Erika Viragh, S. Lawrence Zipursky () and Barry J. Dickson ()
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Daisuke Hattori: Howard Hughes Medical Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90049, USA
Ebru Demir: Institute of Molecular Pathology, Dr. Bohr-gasse 7, Vienna A-1030, Austria
Ho Won Kim: Howard Hughes Medical Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90049, USA
Erika Viragh: Institute of Molecular Pathology, Dr. Bohr-gasse 7, Vienna A-1030, Austria
S. Lawrence Zipursky: Howard Hughes Medical Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90049, USA
Barry J. Dickson: Institute of Molecular Pathology, Dr. Bohr-gasse 7, Vienna A-1030, Austria

Nature, 2007, vol. 449, issue 7159, 223-227

Abstract: Wiring diagram The complexity and specificity of neuronal wiring implies the existence of a cellular recognition code that allows neurons to distinguish between one another. The remarkable diversity of the immunoglobulin superfamily protein Dscam (for Down syndrome cell adhesion molecule) may be part of that system. Dscam plays a crucial role in making Drosophila neurons able to distinguish between self and non-self, and is essential to patterning neural circuits.

Date: 2007
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DOI: 10.1038/nature06099

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