MicroRNA control of Nodal signalling

Graziano Martello, Luca Zacchigna, Masafumi Inui, Marco Montagner, Maddalena Adorno, Anant Mamidi, Leonardo Morsut, Sandra Soligo, Uyen Tran, Sirio Dupont, Michelangelo Cordenonsi, Oliver Wessely and Stefano Piccolo ()
Additional contact information
Graziano Martello: Microbiology and Medical Biotechnologies, Section of Histology and Embryology, University of Padua, viale Colombo 3, 35126 Padua, Italy
Luca Zacchigna: Microbiology and Medical Biotechnologies, Section of Histology and Embryology, University of Padua, viale Colombo 3, 35126 Padua, Italy
Masafumi Inui: Microbiology and Medical Biotechnologies, Section of Histology and Embryology, University of Padua, viale Colombo 3, 35126 Padua, Italy
Marco Montagner: Microbiology and Medical Biotechnologies, Section of Histology and Embryology, University of Padua, viale Colombo 3, 35126 Padua, Italy
Maddalena Adorno: Microbiology and Medical Biotechnologies, Section of Histology and Embryology, University of Padua, viale Colombo 3, 35126 Padua, Italy
Anant Mamidi: Microbiology and Medical Biotechnologies, Section of Histology and Embryology, University of Padua, viale Colombo 3, 35126 Padua, Italy
Leonardo Morsut: Microbiology and Medical Biotechnologies, Section of Histology and Embryology, University of Padua, viale Colombo 3, 35126 Padua, Italy
Sandra Soligo: Microbiology and Medical Biotechnologies, Section of Histology and Embryology, University of Padua, viale Colombo 3, 35126 Padua, Italy
Uyen Tran: LSU Health Sciences Center, 1901 Perdido Street, New Orleans, Louisiana 70112, USA
Sirio Dupont: Microbiology and Medical Biotechnologies, Section of Histology and Embryology, University of Padua, viale Colombo 3, 35126 Padua, Italy
Michelangelo Cordenonsi: Microbiology and Medical Biotechnologies, Section of Histology and Embryology, University of Padua, viale Colombo 3, 35126 Padua, Italy
Oliver Wessely: LSU Health Sciences Center, 1901 Perdido Street, New Orleans, Louisiana 70112, USA
Stefano Piccolo: Microbiology and Medical Biotechnologies, Section of Histology and Embryology, University of Padua, viale Colombo 3, 35126 Padua, Italy

Nature, 2007, vol. 449, issue 7159, 183-188

Abstract: Abstract MicroRNAs are crucial modulators of gene expression, yet their involvement as effectors of growth factor signalling is largely unknown. Ligands of the transforming growth factor-β superfamily are essential for development and adult tissue homeostasis. In early Xenopus embryos, signalling by the transforming growth factor-β ligand Nodal is crucial for the dorsal induction of the Spemann’s organizer. Here we report that Xenopus laevis microRNAs miR-15 and miR-16 restrict the size of the organizer by targeting the Nodal type II receptor Acvr2a. Endogenous miR-15 and miR-16 are ventrally enriched as they are negatively regulated by the dorsal Wnt/β-catenin pathway. These findings exemplify the relevance of microRNAs as regulators of early embryonic patterning acting at the crossroads of fundamental signalling cascades.

Date: 2007
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DOI: 10.1038/nature06100

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