Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU

Mark J. Kiel, Shenghui He, Rina Ashkenazi, Sara N. Gentry, Monica Teta, Jake A. Kushner, Trachette L. Jackson and Sean J. Morrison ()
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Mark J. Kiel: Howard Hughes Medical Institute, Life Sciences Institute, and Centre for Stem Cell Biology
Shenghui He: Howard Hughes Medical Institute, Life Sciences Institute, and Centre for Stem Cell Biology
Rina Ashkenazi: University of Michigan, Ann Arbor, Michigan 48109-2216, USA
Sara N. Gentry: University of Michigan, Ann Arbor, Michigan 48109-2216, USA
Monica Teta: Children’s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Jake A. Kushner: Children’s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Trachette L. Jackson: University of Michigan, Ann Arbor, Michigan 48109-2216, USA
Sean J. Morrison: Howard Hughes Medical Institute, Life Sciences Institute, and Centre for Stem Cell Biology

Nature, 2007, vol. 449, issue 7159, 238-242

Abstract: The not-so-immortal strand In 1975, John Cairns proposed the 'immortal strand' hypothesis as a mechanism by which adult stem cells might minimize accumulation of mutations. This is achieved by selectively retaining chromosomes containing 'old' DNA as shown by the analysis of the DNA strands that incorporate radioactive label or a nucleotide analogue such as bromodeoxyuridine (BrdU). A new contribution to this ongoing debate is published in this issue. Kiel et al. show that the immortal strand model is not a general property of stem cells since it does not apply to haematopoietic stem cells. These cells cannot be identified on the basis of BrdU label retention, and do not retain older DNA during division.

Date: 2007
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DOI: 10.1038/nature06115

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