Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation

Da Jia, Renata Z. Jurkowska, Xing Zhang, Albert Jeltsch () and Xiaodong Cheng ()
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Da Jia: Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322, USA
Renata Z. Jurkowska: Biochemistry Laboratory, School of Engineering and Science, Jacobs University Bremen, Campus Ring 1
Xing Zhang: Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322, USA
Albert Jeltsch: Biochemistry Laboratory, School of Engineering and Science, Jacobs University Bremen, Campus Ring 1
Xiaodong Cheng: Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322, USA

Nature, 2007, vol. 449, issue 7159, 248-251

Abstract: A crystal structure of a complex between the DNA methyltransferase regulatory factor Dnmt3L and the catalytic domain of Dnmt3a leads to a model being proposed for the preferential methylation of DNA on maternally imprinted genes.

Date: 2007
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DOI: 10.1038/nature06146

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