Differential Notch signalling distinguishes neural stem cells from intermediate progenitors

Ken-ichi Mizutani, Keejung Yoon, Louis Dang, Akinori Tokunaga and Nicholas Gaiano ()
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Ken-ichi Mizutani: Institute for Cell Engineering,
Keejung Yoon: Institute for Cell Engineering,
Louis Dang: Institute for Cell Engineering,
Akinori Tokunaga: Institute for Cell Engineering,
Nicholas Gaiano: Institute for Cell Engineering,

Nature, 2007, vol. 449, issue 7160, 351-355

Abstract: Stem cells go up a Notch The existence of different proliferative cell types in most stem cell systems is widely accepted, but the differences between these stem cells and restricted progenitor subsets are poorly understood. Now a team working at Johns Hopkins has discovered how two distinct cell populations in the developing mouse brain — 'true' neural stem cells and similar but less potent progenitors — are distinguished. The stem cells undergo stepwise maturation, gradually shedding 'stem cell' properties. The first step turns stem cells into 'progenitors' by dictating how signals downstream of Notch, a protein that regulates stem cells in many tissues, are transmitted. Then the two cell types diverge and the key factor here is whether a Notch signalling protein called CBF1 is active or not. CBF1 signalling plays the same role in blood stem cells, so it may be be a general 'switch' distinguishing stem cells from progenitors.

Date: 2007
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DOI: 10.1038/nature06090

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