Calcineurin is required to release Xenopus egg extracts from meiotic M phase

Satoru Mochida and Tim Hunt ()
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Satoru Mochida: Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
Tim Hunt: Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK

Nature, 2007, vol. 449, issue 7160, 336-340

Abstract: Calcineurin in fertilization The pathway from fertilization to an increase in the cytosolic Ca2+ concentration in eggs, a pivotal event in egg activation in multicellular organisms, has been clearly established but its downstream pathways are less explored. Two groups now report on this. They identify a new pathway involving the phosphatase, calcineurin. Calcium-induced activation of calcineurin is essential for the initiation of embryonic development in Xenopus, prompting the release of oocytes from a period of cell-cycle arrest in the M phase of meiosis following fertilization. A second wave of phosphatase activity then acts as a gateway to mitosis.

Date: 2007
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DOI: 10.1038/nature06121

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