Generation of functional multipotent adult stem cells from GPR125+ germline progenitors

Marco Seandel, Daylon James, Sergey V. Shmelkov, Ilaria Falciatori, Jiyeon Kim, Sai Chavala, Douglas S. Scherr, Fan Zhang, Richard Torres, Nicholas W. Gale, George D. Yancopoulos, Andrew Murphy, David M. Valenzuela, Robin M. Hobbs, Pier Paolo Pandolfi and Shahin Rafii ()
Additional contact information
Marco Seandel: Howard Hughes Medical Institute, and
Daylon James: Howard Hughes Medical Institute, and
Sergey V. Shmelkov: Howard Hughes Medical Institute, and
Ilaria Falciatori: Howard Hughes Medical Institute, and
Jiyeon Kim: Howard Hughes Medical Institute, and
Sai Chavala: Howard Hughes Medical Institute, and
Douglas S. Scherr: Weill Cornell Medical College, New York 10065, USA
Fan Zhang: Howard Hughes Medical Institute, and
Richard Torres: Regeneron Pharmaceuticals, Tarrytown, New York 10591, USA
Nicholas W. Gale: Regeneron Pharmaceuticals, Tarrytown, New York 10591, USA
George D. Yancopoulos: Regeneron Pharmaceuticals, Tarrytown, New York 10591, USA
Andrew Murphy: Regeneron Pharmaceuticals, Tarrytown, New York 10591, USA
David M. Valenzuela: Regeneron Pharmaceuticals, Tarrytown, New York 10591, USA
Robin M. Hobbs: Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York 10065, USA
Pier Paolo Pandolfi: Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York 10065, USA
Shahin Rafii: Howard Hughes Medical Institute, and

Nature, 2007, vol. 449, issue 7160, 346-350

Abstract: Stem cells make their mark Adult stem cells are an attractive alternative to embryonic stem cells for therapeutic use. As yet there is no standard method for obtaining such cells from adults and priming them to form different tissues, but a new system that generates large numbers of stem cells from the adult testicle shows promise. It makes use of a novel marker, an orphan receptor known as GPR125, found on the surface of spermatogonial stem cells. The use of specialized feeder cells to support stem cell growth allows stem cells once destined for spermatogenesis to become multipotent. This work also provides clues as to the minimal requirements for multipotency in adult cells.

Date: 2007
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DOI: 10.1038/nature06129

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