Transient activation of calcineurin is essential to initiate embryonic development in Xenopus laevis

Tomoko Nishiyama, Norio Yoshizaki, Takeo Kishimoto and Keita Ohsumi ()
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Tomoko Nishiyama: Laboratory of Cell and Developmental Biology, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan
Norio Yoshizaki: United Graduate School of Agricultural Science, Gifu University
Takeo Kishimoto: Laboratory of Cell and Developmental Biology, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan
Keita Ohsumi: Laboratory of Cell and Developmental Biology, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan

Nature, 2007, vol. 449, issue 7160, 341-345

Abstract: Calcineurin in fertilization The pathway from fertilization to an increase in the cytosolic Ca2+ concentration in eggs, a pivotal event in egg activation in multicellular organisms, has been clearly established but its downstream pathways are less explored. Two groups now report on this. They identify a new pathway involving the phosphatase, calcineurin. Calcium-induced activation of calcineurin is essential for the initiation of embryonic development in Xenopus, prompting the release of oocytes from a period of cell-cycle arrest in the M phase of meiosis following fertilization. A second wave of phosphatase activity then acts as a gateway to mitosis.

Date: 2007
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DOI: 10.1038/nature06136

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