IgH class switching and translocations use a robust non-classical end-joining pathway

Catherine T. Yan, Cristian Boboila, Ellen Kris Souza, Sonia Franco, Thomas R. Hickernell, Michael Murphy, Sunil Gumaste, Mark Geyer, Ali A. Zarrin, John P. Manis, Klaus Rajewsky and Frederick W. Alt ()
Additional contact information
Catherine T. Yan: Howard Hughes Medical Institute,
Cristian Boboila: Howard Hughes Medical Institute,
Ellen Kris Souza: Howard Hughes Medical Institute,
Sonia Franco: Howard Hughes Medical Institute,
Thomas R. Hickernell: Howard Hughes Medical Institute,
Michael Murphy: Howard Hughes Medical Institute,
Sunil Gumaste: Howard Hughes Medical Institute,
Mark Geyer: The Children’s Hospital,
Ali A. Zarrin: Howard Hughes Medical Institute,
John P. Manis: The Children’s Hospital,
Klaus Rajewsky: Immune Disease Institute,
Frederick W. Alt: Howard Hughes Medical Institute,

Nature, 2007, vol. 449, issue 7161, 478-482

Abstract: Programmed DNA breaks are made and repaired at two points during the development of antibody-producing B cells. While the breaks occurring during V(D)J recombination utilize factors that promote non-homologous end joining, this study finds that breaks that happen during class switch recombination require only a subset of these factors, suggesting that there are other as-yet-unrecognized proteins that function in this process.

Date: 2007
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DOI: 10.1038/nature06020

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