Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors

César Cobaleda, Wolfram Jochum and Meinrad Busslinger ()
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César Cobaleda: Research Institute of Molecular Pathology, Vienna Biocenter, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
Wolfram Jochum: University Hospital, Schmelzbergstrasse 12, CH-8091 Zürich, Switzerland
Meinrad Busslinger: Research Institute of Molecular Pathology, Vienna Biocenter, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria

Nature, 2007, vol. 449, issue 7161, 473-477

Abstract: Differentiation reversed How the identity of mature, differentiated cell types is controlled and what degree of developmental plasticity can still be realized by fully differentiated cell types is an important and fundamental question in developmental biology and stem cell research. A central question in this field, that of whether cells are reprogrammed directly to a different cell type — by direct transdifferentiation — or take a backward step to a more immature state before moving along another pathway — called dedifferentiation — is answered by a report in this issue. Cobaleda et al. demonstrate dedifferentiation during the conversion of mature B lymphoid cells to functional T cells. Deletion of Pax5, a transcription factor important for B cell differentiation and function, caused mature B cells to dedifferentiate into progenitor cells that can give rise to T cells. Pax5 is also known to play a role in cancer, and its loss is shown to induce lymphomas that arise from progenitor cells.

Date: 2007
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DOI: 10.1038/nature06159

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