Rag mutations reveal robust alternative end joining

Barbara Corneo, Rebecca L. Wendland, Ludovic Deriano, Xiaoping Cui, Isaac A. Klein, Serre-Yu Wong, Suzzette Arnal, Abigail J. Holub, Geoffrey R. Weller, Bette A. Pancake, Sundeep Shah, Vicky L. Brandt, Katheryn Meek and David B. Roth ()
Additional contact information
Barbara Corneo: New York University School of Medicine, New York, New York 10016, USA
Rebecca L. Wendland: New York University School of Medicine, New York, New York 10016, USA
Ludovic Deriano: New York University School of Medicine, New York, New York 10016, USA
Xiaoping Cui: College of Veterinary Medicine, Pathobiology & Diagnostic Investigation, Michigan State University, East Lansing, Michigan 48824, USA
Isaac A. Klein: New York University School of Medicine, New York, New York 10016, USA
Serre-Yu Wong: New York University School of Medicine, New York, New York 10016, USA
Suzzette Arnal: New York University School of Medicine, New York, New York 10016, USA
Abigail J. Holub: New York University School of Medicine, New York, New York 10016, USA
Geoffrey R. Weller: New York University School of Medicine, New York, New York 10016, USA
Bette A. Pancake: New York University School of Medicine, New York, New York 10016, USA
Sundeep Shah: Baylor College of Medicine, Houston, Texas 77030, USA
Vicky L. Brandt: New York University School of Medicine, New York, New York 10016, USA
Katheryn Meek: College of Veterinary Medicine, Pathobiology & Diagnostic Investigation, Michigan State University, East Lansing, Michigan 48824, USA
David B. Roth: New York University School of Medicine, New York, New York 10016, USA

Nature, 2007, vol. 449, issue 7161, 483-486

Abstract: In the process of generating antibody diversity, DNA in the V(D)J locus undergoes programmed double-strand breaks that are made by the Rag1–Rag 2 complex. These breaks are repaired by the non-homologous end-joining (NHEJ) pathway. Cells deficient in NHEJ factors show very low levels of recombinants, so it was believed there might be another repair pathway. But this paper shows that an alternative NHEJ pathway exists, and that it functions at low levels even in wild-type cells.

Date: 2007
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DOI: 10.1038/nature06168

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