Taking dendritic cells into medicine

Ralph M. Steinman () and Jacques Banchereau
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Ralph M. Steinman: The Rockefeller University
Jacques Banchereau: Baylor Institute for Immunology Research, Dallas, Texas 75204, USA

Nature, 2007, vol. 449, issue 7161, 419-426

Abstract: Cells with connections Dendritic cells are found in the blood and in tissues exposed to the environment, such as the skin and the lining of the nose, lungs and stomach. Their job is to adjust innate and adaptive immune responses to the environmental stimulus at hand. In a review, Ralph Steinman (awarded the Laskar prize last week in recognition of his discovery of dendritic cells) and Jacques Banchereau discuss the medically relevant properties of dendritic cells. Pathogens and tumours can exploit dendritic cells to evade immunity, making them logical drug targets. They can also generate resistance: during allergy, autoimmunity and transplant rejection, dendritic cells may instigate unwanted responses, but they can also silence these conditions.

Date: 2007
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DOI: 10.1038/nature06175

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