Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide

Roberto Lande, Josh Gregorio, Valeria Facchinetti, Bithi Chatterjee, Yi-Hong Wang, Bernhard Homey, Wei Cao, Yui-Hsi Wang, Bing Su, Frank O. Nestle, Tomasz Zal, Ira Mellman, Jens-Michael Schröder, Yong-Jun Liu and Michel Gilliet ()
Additional contact information
Roberto Lande: and
Josh Gregorio: and
Valeria Facchinetti: and
Bithi Chatterjee: Yale University School of Medicine, New Haven, Connecticut 06520-8002, USA
Yi-Hong Wang: and
Bernhard Homey: Heinrich-Heine-University, Düsseldorf 40225, Germany
Wei Cao: and
Yui-Hsi Wang: and
Bing Su: and
Frank O. Nestle: St John’s Institute of Dermatology, King’s College London School of Medicine
Tomasz Zal: and
Ira Mellman: Yale University School of Medicine, New Haven, Connecticut 06520-8002, USA
Jens-Michael Schröder: University Hospital Schleswig-Holstein, Campus Kiel, University of Kiel
Yong-Jun Liu: and
Michel Gilliet: and

Nature, 2007, vol. 449, issue 7162, 564-569

Abstract: Abstract Plasmacytoid dendritic cells (pDCs) sense viral and microbial DNA through endosomal Toll-like receptors to produce type 1 interferons. pDCs do not normally respond to self-DNA, but this restriction seems to break down in human autoimmune disease by an as yet poorly understood mechanism. Here we identify the antimicrobial peptide LL37 (also known as CAMP) as the key factor that mediates pDC activation in psoriasis, a common autoimmune disease of the skin. LL37 converts inert self-DNA into a potent trigger of interferon production by binding the DNA to form aggregated and condensed structures that are delivered to and retained within early endocytic compartments in pDCs to trigger Toll-like receptor 9. Thus, our data uncover a fundamental role of an endogenous antimicrobial peptide in breaking innate tolerance to self-DNA and suggest that this pathway may drive autoimmunity in psoriasis.

Date: 2007
References: Add references at CitEc
Citations: View citations in EconPapers (5)

Downloads: (external link)
https://www.nature.com/articles/nature06116 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:449:y:2007:i:7162:d:10.1038_nature06116

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature06116

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().