Mechanism of chloride interaction with neurotransmitter:sodium symporters

Elia Zomot, Annie Bendahan, Matthias Quick, Yongfang Zhao, Jonathan A. Javitch and Baruch I. Kanner ()
Additional contact information
Elia Zomot: Hebrew University Hadassah Medical School, POB 12272, Jerusalem 91120, Israel
Annie Bendahan: Hebrew University Hadassah Medical School, POB 12272, Jerusalem 91120, Israel
Matthias Quick: Center for Molecular Recognition and,
Yongfang Zhao: Center for Molecular Recognition and,
Jonathan A. Javitch: Center for Molecular Recognition and,
Baruch I. Kanner: Hebrew University Hadassah Medical School, POB 12272, Jerusalem 91120, Israel

Nature, 2007, vol. 449, issue 7163, 726-730

Abstract: Neurotransmitter transport A landmark paper in structural biology recently documented the crystal structure of LeuT, a bacterial homologue of Na+/Cl−-dependent neurotransmitter transporters. In this homologue the transporter binds to two sodium ions and a substrate molecule. In the real neurotransmitter transporters of this family, chloride is co-transported with sodium and the neurotransmitter. Zomot et al. apply structural and mechanistic knowledge of LeuT, and a chloride transporter from an entirely different family, to mammalian neurotransmitter:sodium symporter (NSS) transporters, including GAT-1. They find that transported chloride ions serve to neutralize the positive charge carried by the sodium ions, and establish the probable location of the binding site for chloride, right next to one of the sodium ions. The mechanism of these transporters is of particular interest because of their role in the regulation of neurotransmission and as the site of action of drugs such as Prozac (fluoxetine).

Date: 2007
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/nature06133 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:449:y:2007:i:7163:d:10.1038_nature06133

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature06133

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().