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UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development

Karl Agger, Paul A. C. Cloos, Jesper Christensen, Diego Pasini, Simon Rose, Juri Rappsilber, Irina Issaeva, Eli Canaani, Anna Elisabetta Salcini and Kristian Helin ()
Additional contact information
Karl Agger: Biotech Research and Innovation Centre (BRIC), and,
Paul A. C. Cloos: Biotech Research and Innovation Centre (BRIC), and,
Jesper Christensen: Biotech Research and Innovation Centre (BRIC), and,
Diego Pasini: Biotech Research and Innovation Centre (BRIC), and,
Simon Rose: Biotech Research and Innovation Centre (BRIC), and,
Juri Rappsilber: Wellcome Trust Centre for Cell Biology, University of Edinburgh
Irina Issaeva: Weizmann Institute of Science
Eli Canaani: Weizmann Institute of Science
Anna Elisabetta Salcini: Biotech Research and Innovation Centre (BRIC), and,
Kristian Helin: Biotech Research and Innovation Centre (BRIC), and,

Nature, 2007, vol. 449, issue 7163, 731-734

Abstract: Two human JmjC-domain-containing enzymes are shown to catalyse demethylation of histone H3K27me3, a histone modification mediated by polycomb proteins and associated with stem cell maintenance and differentiation

Date: 2007
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DOI: 10.1038/nature06145

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