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Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4

Takayuki Obita, Suraj Saksena, Sara Ghazi-Tabatabai, David J. Gill, Olga Perisic, Scott D. Emr and Roger L. Williams ()
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Takayuki Obita: MRC Laboratory of Molecular Biology, Medical Research Council Centre
Suraj Saksena: Biotechnology Building, Cornell University, Ithaca, New York 14853, USA
Sara Ghazi-Tabatabai: MRC Laboratory of Molecular Biology, Medical Research Council Centre
David J. Gill: MRC Laboratory of Molecular Biology, Medical Research Council Centre
Olga Perisic: MRC Laboratory of Molecular Biology, Medical Research Council Centre
Scott D. Emr: Biotechnology Building, Cornell University, Ithaca, New York 14853, USA
Roger L. Williams: MRC Laboratory of Molecular Biology, Medical Research Council Centre

Nature, 2007, vol. 449, issue 7163, 735-739

Abstract: In yeast, two ESCRT-III-related subunits, Vps2 and Did2 bind to Vps4. The crystal structure of Vps2 bound to Vp4 s is presented, elucidating the basis for selective recognition of the ESCRT-III complex.

Date: 2007
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DOI: 10.1038/nature06171

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