The equilibria that allow bacterial persistence in human hosts

Martin J. Blaser () and Denise Kirschner
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Martin J. Blaser: New York University School of Medicine, New York, New York 10016, USA
Denise Kirschner: University of Michigan Medical School, Ann Arbor, Michigan 48109, USA

Nature, 2007, vol. 449, issue 7164, 843-849

Abstract: Getting to know you Microbial persistence in hosts is usually not accidental, but reflects a shared merging of the biology of two or more disparate life-forms. Martin Blaser and Denise Kirschner advance the hypothesis that there has been selection for both microbes and hosts to maximize the fitness of both parties to a life involving parasitism or symbiosis, conforming to an evolutionarily stable strategy. They develop a model that can account for the persistence of three very different types of interaction between microbes in humans — involving Helicobacter pylori, Salmonella typhi and Mycobacterium tuberculosis.

Date: 2007
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DOI: 10.1038/nature06198

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