Interferon modulation of cellular microRNAs as an antiviral mechanism

Irene M. Pedersen, Guofeng Cheng, Stefan Wieland, Stefano Volinia, Carlo M. Croce, Francis V. Chisari and Michael David ()
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Irene M. Pedersen: Department of Molecular Biology,
Guofeng Cheng: The Scripps Research Institute, La Jolla, California 92037, USA
Stefan Wieland: The Scripps Research Institute, La Jolla, California 92037, USA
Stefano Volinia: Immunology & Medical Genetics, Ohio State University, Columbus, Ohio 43210, USA
Carlo M. Croce: Immunology & Medical Genetics, Ohio State University, Columbus, Ohio 43210, USA
Francis V. Chisari: The Scripps Research Institute, La Jolla, California 92037, USA
Michael David: Department of Molecular Biology,

Nature, 2007, vol. 449, issue 7164, 919-922

Abstract: Antiviral miRNA Plants and invertebrates can use RNA silencing as a protective mechanism in viral infection. Now cellular microRNAs (miRNAs) have been found to have an antiviral function in mammalian cells too. Interferon-β is involved in the regulation of a number of cellular miRNAs in human cells, and eight of these are active against sequences on the hepatitis C virus. In addition, modulation of cellular miRNA levels are found to contribute significantly towards the antiviral effects of interferon-β, suggesting that they are a functioning component of the mammalian innate immune response.

Date: 2007
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DOI: 10.1038/nature06205

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