Clathrate nanostructures for mass spectrometry

Trent R. Northen, Oscar Yanes, Michael T. Northen, Dena Marrinucci, Winnie Uritboonthai, Junefredo Apon, Stephen L. Golledge, Anders Nordström and Gary Siuzdak ()
Additional contact information
Trent R. Northen: Department of Molecular Biology,
Oscar Yanes: Department of Molecular Biology,
Michael T. Northen: University of California at Santa Barbara, Santa Barbara, California 93106, USA
Dena Marrinucci: The Scripps Research Institute, La Jolla, California 92037, USA
Winnie Uritboonthai: Department of Molecular Biology,
Junefredo Apon: Department of Molecular Biology,
Stephen L. Golledge: CAMCOR Surface Analysis Facility at the University of Oregon, Eugene, Oregon 97403, USA
Anders Nordström: Department of Molecular Biology,
Gary Siuzdak: Department of Molecular Biology,

Nature, 2007, vol. 449, issue 7165, 1033-1036

Abstract: Explosive spectrometry Mass spectrometry has great potential for detecting biomolecules, but existing methods have several drawbacks, including a lack of sensitivity and the need for a matrix of molecules to promote analyte ionization. A dramatic new technique, using laser or ion beams to vaporize materials from nano-scale capsules, could overcome these limitations. It involves a specially prepared surface containing 'initiator' molecules that erupt violently when irradiated. This explosion releases ionized analyte molecules that were adsorbed to the surface, freeing them for detection. The method, dubbed NIMS (for nanostructure-initiator mass spectrometry), can analyse very small areas with extremely high sensitivity, allowing analysis of peptide microarrays, blood, urine and single cells, and it can even be used for tissue imaging.

Date: 2007
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DOI: 10.1038/nature06195

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