Functional architecture of the retromer cargo-recognition complex

Aitor Hierro, Adriana L. Rojas, Raul Rojas, Namita Murthy, Grégory Effantin, Andrey V. Kajava, Alasdair C. Steven, Juan S. Bonifacino and James H. Hurley ()
Additional contact information
Aitor Hierro: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases,
Adriana L. Rojas: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases,
Raul Rojas: Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, and,
Namita Murthy: Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, and,
Grégory Effantin: Laboratory of Structural Biology, National Institute of Arthritis, Musculoskeletal, and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Andrey V. Kajava: Centre de Recherches de Biochimie Macromoléculaire, CNRS, University of Montpellier, 1919 Route de Mende, 34293 Montpellier, France
Alasdair C. Steven: Laboratory of Structural Biology, National Institute of Arthritis, Musculoskeletal, and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Juan S. Bonifacino: Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, and,
James H. Hurley: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases,

Nature, 2007, vol. 449, issue 7165, 1063-1067

Abstract: The retromer is a complex of Vacuolar protein sorting proteins that mediate retrieval of lysosomal hydrolases from endosomes to the trans golgi network. The human retromer complex can be separated into two smaller complexes, a membrane targeting sorting nexin dimer and a heterotrimeric cargo recognition complex. New and previously solved structures, bioinformatics, interaction studies, molecular modelling and electron microscopy of the entire complex are combined to develop a structural model of the complex.

Date: 2007
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DOI: 10.1038/nature06216

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